682738-42-7

Basic information

• Product Name: 4-[3-fluoro-5-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine
• Synonyms: 4-[3-fluoro-5-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine
• CAS NO: 682738-42-7
• Molecular Weight: 262.231
• Mol File: 682738-42-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-[3-fluoro-5-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[3-fluoro-5-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine(682738-42-7)
• EPA Substance Registry System: 4-[3-fluoro-5-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine(682738-42-7)

Safety Data

• Hazardous Substances Data: 682738-42-7(Hazardous Substances Data)

Upstream product

• 17356-08-0 thiourea 
• 202664-54-8 1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone 

Relevant articles and documents

Design, synthesis, and structure–activity relationships study of n-pyrimidyl/pyridyl-2-thiazolamine analogues as novel positive allosteric modulators of M3 muscarinic acetylcholine receptor

The M3 muscarinic acetylcholine receptor (mAChR) plays an essential pharmacological role in mediating a broad range of actions of acetylcholine (ACh) released throughout the periphery and central nerve system (CNS). Nevertheless, its agonistic functions remain unclear due to the lack of available subtype-selective agonists or positive allosteric modulators (PAMs). In the course of our extended structure–activity relationships (SARs) study on 2-acylaminothiazole derivative 1, a previously reported PAM of the M3 mAChR, we successfully identified N-pyrimidyl/pyridyl-2-thiazolamine analogues as new scaffolds. The SARs study was rationalized using conformational analyses based on intramolecular interactions. A comprehensive study of a series of analogues described in this paper suggests that a unique sulfur–nitrogen nonbonding interaction in the N-pyrimidyl/pyridyl-2-thiazolamine moiety enable conformations that are essential for activity. Further, a SARs study around the N-pyrimidyl/pyridyl-2-thiazolamine core culminated in the discovery of compound 3g, which showed potent in vitro PAM activity for the M3 mAChR with excellent subtype selectivity. Compound 3g also showed a distinct pharmacological effect on isolated smooth muscle tissue from rat bladder and favorable pharmacokinetics profiles, suggesting its potential as a chemical tool for probing the M3 mAChR in further research.

2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF

To provide a compound useful as an active ingredient of a pharmacological composition for the treatment of urinary storage symptoms, dysuria, lower urinary tract diseases, and the like. [Solution] The inventors perfected the present invention after discov

FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS

The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl. Formula (I)