682769-43-3

Basic information

• Product Name: 2-Propen-1-one, 3-[[4-amino-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4- methylphenyl)-3-(5-nitro-2-furanyl)-, (2Z)-
• CAS NO: 682769-43-3
• Molecular Formula: C24H21N5O5S
• Molecular Weight: 491.527
• Mol File: 682769-43-3.mol

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-[[4-amino-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4- methylphenyl)-3-(5-nitro-2-furanyl)-, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-[[4-amino-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4- methylphenyl)-3-(5-nitro-2-furanyl)-, (2Z)-(682769-43-3)
• EPA Substance Registry System: 2-Propen-1-one, 3-[[4-amino-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4- methylphenyl)-3-(5-nitro-2-furanyl)-, (2Z)-(682769-43-3)

Safety Data

• Hazardous Substances Data: 682769-43-3(Hazardous Substances Data)

Upstream product

• 32023-48-6 1-(p-tolyl)-3-(5-nitro-2-furyl)-2-propyn-1-one 
• 113766-05-5 3-p-tolyoxymethyl-4-amino-5-mercapto-(4H)-1,2,4-triazole 
• 122-00-9 para-methylacetophenone 
• 92-55-7 5-nitro-2-furfuraldehyde diacetate 
• 32023-51-1 2,3-Dibromo-3-(5-nitro-furan-2-yl)-1-p-tolyl-propan-1-one 
• 32023-50-0 1-(4-methylphenyl)-3-(5-nitro-2-furyl) prop-2-en-1-one 

Relevant articles and documents

Synthesis and antibacterial properties of nitrofuryltriazolothiadiazepines

Methyl aryl ketones 1 on reaction with 5-nitrofurfuraldehyde 2 give 1-aryl-3-(5-nitro-2-furyl)-2-propen-1-ones 3 which on bromination affords 2,3-dibromo-1-aryl-3-(5-nitro-2-furyl)-2-propen-1-ones 4. Debromination of 4 by triethylamine in benzene results in 1-aryl-3-(5-nitro-2-furyl)-2-propen-1-ones 5 which on condensation with 3-substituted-4-amino-5-mercapto-1,2,4-triazole 6 furnishes Michael adducts 7. The Michael adduct 7 undergoes cyclization in conc. sulphuric acid to give 3-aryloxymethyl-6-aryl-8-(5-nitro-2-furyl)-1,2,4-triazolothiadiazepines 8. Antibacterial activity of 7 and 8 has been reported.