682772-55-0Relevant academic research and scientific papers
PD-1 inhibitor as well as preparation method and application thereof
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Paragraph 0274-0276, (2021/03/31)
The present invention relates to a compound represented by a formula I, racemates, stereoisomers, tautomers, isotope markers, nitrogen oxide, solvates, polymorphs, metabolites, esters, prodrugs or pharmaceutically acceptable salts thereof, a pharmaceutical composition containing the compounds, a preparation method and a medical use of the compounds, wherein the structure of the formula I is shownin the specification.
Isotopic labelling of quercetin 3-glucoside
Caldwell, Stuart T.,Petersson, Hanna M.,Farrugia, Louis J.,Mullen, William,Crozier, Alan,Hartley, Richard C.
, p. 7257 - 7265 (2007/10/03)
The potentially important dietary antioxidant, quercetin 3-O-β-d-glucoside, has been 13C-labelled at C-2 of the flavonoid unit by synthesis in 15% yield over five steps from [13C]carbon dioxide. The route is appropriate for radiochemical synthesis. Formation of the protected 3-glucosylated flavonol appears to result from [1,7]-sigmatropic rearrangement with migration of a benzyl group followed by cyclisation. A free 5-OH results even when a phosphazene superbase is used.
Synthesis of 2H-1,5-benzodioxepin and 2,5-dihydro-1,6-benzodioxocin derivatives via ring-closing metathesis reaction
Mamouni,Soukri,Lazar,Akssira,Guillaumet
, p. 2631 - 2633 (2007/10/03)
The synthesis of various 2H-1,5-benzodioxepin and 2,5-dihydro-1,6- benzodioxocin derivatives is described. The key step involves the construction of seven- and eight-membered rings via ring-closing metathesis reaction.
