68281-66-3

Usage

Uses

Used in Research and Development:
6-Chloro-chroman-3-carboxylic acid methyl ester is used as a research compound for the exploration of its chemical properties and potential applications in synthetic chemistry. Its unique structure and the presence of a chlorine atom and methyl ester group make it an interesting candidate for further investigation.
Used in Synthetic Chemistry:
In the field of synthetic chemistry, 6-chloro-chroman-3-carboxylic acid methyl ester is employed as a building block or intermediate in the synthesis of more complex molecules. Its structural features allow for various chemical reactions and modifications, which can lead to the development of new compounds with potential applications in various industries.

Upstream product

• 186581-53-3 diazomethane 
• 164265-01-4 (+/-)-6-chloro-2,3-dihydro-4H-1-benzopyran-3-carboxylic acid 
• 68281-65-2 methyl 6-chloro-2H-1-benzopyran-3-carboxylate 

Relevant academic research and scientific papers

Lipase-mediated kinetic resolution of rigid clofibrate analogues with lipid-modifying activity

The lipase-catalysed kinetic resolution of methyl esters of (±)-5-chloro-2,3-dihydro-1-benzofuran-2-carboxylic acid, (±)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid, and (±)-6-chloro-2,3-dihydro-4H-1-benzopyran-3-carboxylic acid, rigid analogues of clofibrate, was effected with fair to moderate enantioselectivities (E = 1.0-4.8), enantiomeric excesses of up to 86% and workable reaction rates. Enantiomerically pure (R)- and (S)-5-chloro-2,3-dihydro-1-benzofuran-2-carboxylic acids were obtained by fractional crystallisation of the diastereomeric salts of the corresponding racemic acid with (+)- and (-)-amphetamine from ethanol; the absolute configuration of the products were established by chemical correlation.

Benzopyrancarboxamides

Novel 3,4-dihydro-N-(2-propenyl)-2H-1-benzopyran-2(or 3)-carboxamides useful as lipogenesis inhibitors in mammals.