68281-91-4Relevant academic research and scientific papers
PHARMACOLOGICALLY ACTIVE COMPOUNDS
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, (2008/06/13)
There are provided compounds of the general formula (I) and physiologically acceptable salts thereof in which Z represents a group wherein R2 represents a hydrogen atom or a straight or branched chain alkyl radical, or Z can additionally represent a group and R1, R3 and R4, which may be the same or different, each represent a hydrogen atom, a cycloalkyl group, an aryl group which may optionally be substituted by one or more hydroxy, alkoxy, or halogen radicals, or a straight or branched alkyl or alkenyl group, which alkyl or alkenyl group may be substituted with an aryl group, which aryl group may optionally be substituted by one or more hydroxy, alkoxy or halogen radicals. The compounds possess spasmolytic and cAMP phosphodiesterase inhibitory activity
Bicyclic Heterocycles with Nitrogen at the Ring Junction. Part 2. Application of the Dakin-West Reaction to the Synthesis of Imidazo-1,2,4-triazin-4(3H)-ones
Charles, Isabel,Latham, David W. S.,Hartley, David,Oxford, Alexander W.,Scopes, David I. C.
, p. 1139 - 1146 (2007/10/02)
A series of novel acylamino α-keto-esters (4) have been prepared via a Dakin-West reaction of acylated α-amino-acids and ethyl oxalyl chloride.Their use in a general synthesis of imidazo-1,2,4-triazin-4(3H)-ones (7) is described.The conversion of t
