68284-01-5

Usage

Uses

Used in Pharmaceutical Research:
4-TERT-BUTYL-BENZAMIDINE HCL is used as a research compound for its potential anti-cancer properties, given its ability to inhibit certain enzymes and proteins that are implicated in cancer development and progression.
Used in Organic Synthesis:
In the field of organic synthesis, 4-TERT-BUTYL-BENZAMIDINE HCL is utilized as a building block or intermediate in the synthesis of more complex organic molecules, contributing to the development of new pharmaceuticals and other chemical products.
Used in Anti-inflammatory Applications:
4-TERT-BUTYL-BENZAMIDINE HCL is used as an anti-inflammatory agent, potentially mitigating inflammation by targeting specific molecular pathways involved in inflammatory responses.
Used in Anti-coagulant Drug Development:
Due to its anti-coagulant properties, 4-TERT-BUTYL-BENZAMIDINE HCL is used in the development of new drugs aimed at preventing blood clot formation, which is crucial for the treatment and management of various cardiovascular conditions.

Upstream product

• 4210-32-6 4-tert-butyl benzonitrile 

Downstream Products

• 125772-43-2 4-t-butylbenzamidinium formate 
• 125772-51-2 4-t-butylbenzamidinium acetate 
• 125772-65-8 4-t-butylbenzamidinium pyruvate 
• 125772-58-9 4-t-butylbenzamidinium trifluoracetate 
• 945212-41-9 2-(4-tert-butylphenyl)-4,6-dihydroxypyrimidine 
• 442128-64-5 4,6-bis(2-amino-3-formylpyridyl)-2-(4-tert-butylphenyl)pyrimidine 
• 442128-34-9 1-[6-acetyl-2-(4-tert-butylphenyl)-pyrimidin-4-yl]-ethyl ketone 
• 442128-03-2 2-(4-tert-butylphenyl)-4,6-dichloropyrimidine 
• 475560-48-6 2-(4-tert-butylphenyl)-4,6-bis(7-pyridin-2-yl[1,8]naphthyridin-2-yl)pyrimidine 

Relevant academic research and scientific papers

Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338

We report herein an efficient, stereocontrolled, and chromatography-free synthesis of the novel broad spectrum antibiotic GDC-5338. The route features the construction of a functionalized tripeptide backbone, a high-yielding macrocyclization via a Pd-catalyzed Suzuki-Miyaura reaction, and the late-stage elaboration of key amide bonds with minimal stereochemical erosion. Through extensive reaction development and analytical understanding, these key advancements allowed the preparation of GDC-5338 in 17 steps, 15% overall yield, >99 A % HPLC, and >99:1 dr.

Naphthyridine-based helical foldamers and macrocycles: Synthesis, cation binding, and supramolecular assemblies

(Figure Presented) Unraveling the factors that control the conformation of molecular chains is of great interest both for understanding the shape of biological molecular strands and for designing artificial ones that adopt desired forms. Thus, a variety of artificial folding codons have been identified that enforce the formation, among others, of helices, strands, and loops, the major emphasis being on the shape of the foldamer. We report herein the synthesis and study of a family of foldamers and macrocycles based on the 1,8-naphthyridine and pyrimidine units, whose internal cavity is large enough to accommodate ionic substrates, and focus on the impact of guest binding within a cylindrical environment. Interestingly, the binding event within these large oligomers is translated to the outside of the receptors and affects the interaction of the overall complexes with the outside world. For instance, alkali cations bind to the one-turn helices and macrocycles to promote fibril formation and aggregation. Also, polyammonium substrates are able to tune the length of the overall helix assemblies and the rigidity of long oligomers. The reported data on one-turn, two-turn helices and macrocycles not only allows one to devise a model for the ion-controlled supramolecular assembly of such systems but also provides evidence that such controlled scaffolds bear promise in the design of complex systems.

Multicomponent supramolecular devices: Synthesis, optical, and electronic properties of bridged bis-dirhodium and -diruthenium complexes

Four ruthenium- and rhodium-based metal-metal-bonded multicomponent systems have been synthesized, and their absorption, redox, spectroelectrochemical and structural properties have been studied. The absorption spectra of the four bis-dimetallic compounds

Understanding binding affinity: A combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin

The binding of a series of p-alkylbenzamidinium chloride inhibitors to the serine proteinase trypsin over a range of temperatures has been studied using isothermal titration (micro)calorimetry and molecular dynamics simulation techniques. The inhibitors h