68301-87-1

Usage

General Description

2-AMINO-6-TERT-BUTYL-3-FORMYLCHROMONE is a chemical compound with the molecular formula C15H15NO2. It is also known as 6-tert-butyl-2-aminoflavanone. 2-AMINO-6-TERT-BUTYL-3-FORMYLCHROMONE is a derivative of chromone, a naturally occurring chemical compound found in many types of plants. It is used in the pharmaceutical industry as a precursor for the synthesis of various pharmaceutical drugs. 2-AMINO-6-TERT-BUTYL-3-FORMYLCHROMONE has also shown potential as an antioxidant and for its anti-inflammatory properties. It is important to handle 2-AMINO-6-TERT-BUTYL-3-FORMYLCHROMONE with care as it may pose health and environmental risks if not used properly.

Upstream product

• 68301-74-6 6-tert-Butyl-4-oxo-4H-chromene-3-carbonitrile 

Relevant academic research and scientific papers

Studies on antianaphylactic agents. 7. Synthesis of antiallergic 5-oxo-5H-[1]benzopyrano[2,3-b]pyridines

5-Oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acids 23 and their tetrazole analogues 24 were synthesized from 4-oxo-4H-1-benzopyran-3-carbonitriles or 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehydes. When administered intravenously, they exhibited antiallergic activity in a reaginic PCA test in rats. In the carboxylic acid series, the activity was influenced by the substituents at the 2-position and increased substantially in the following order: Me, OMe 2 OH, H NHOMe. On the other hand, in the tetrazole series, 2-unsubsitituted derivatives showed the highest activity. Regardless of the kinds of substituents at positions 2 and 3, compounds bearing an alkyl group, especially an isopropyl group at the 7-position, were superior in activity to the corresponding unsubstituted compounds. Among these alkyl derivatives, 3-carboxylic acid derivatives, i.e., 23c (7-ethyl), 23g (2-amino-7-isopropyl), 23r [2-(methoxyamino)-7-isopropyl], and a 3-tetrazole derivative 24c (7-isopropyl), were 41-184 times as potent as disodium cromoglycate. They also exhibited remarkable activity when administered orally; clinical studies on 23g (AA-673) are in progress.

SYNTHESIS OF 3-SUBSTITUTED-5-OXO-5H-BENZOPYRANOPYRIDINE DERIVATIVES

3-Cyano-. 3-alkoxycarbonyl-, and 3-formyl-5-oxo-5H-benzopyranopyridine dervatives were prepared by reactions of 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehydes 1 with acetylene derivatives (methods A-C) or with reactive methylene compounds (methods D-E) and also by catalytic hydrogenation of 2-chloro-5-oxo-5H-benzopyranopyridine-3-carbonitriles 12 (method F).