68302-12-5

Usage

Uses

Used in Pharmaceutical Research and Development:
2-AMINO-7-ISOPROPYL-5-OXO-5 H-[1]BENZOPYRANO[2,3-B]PYRIDINE-3-CARBONITRILE is used as a potential drug candidate for the development of new medications. Its biological activity and unique chemical structure make it a promising compound for further studies and exploration in the pharmaceutical industry.
Further studies are required to fully understand the properties and potential uses of this chemical compound, as it may have applications in treating various diseases and conditions.

InChI:InChI=1/C16H13N3O2/c1-8(2)9-3-4-13-11(5-9)14(20)12-6-10(7-17)15(18)19-16(12)21-13/h3-6,8H,1-2H3,(H2,18,19)

Upstream product

• 50743-32-3 6-isopropyl-4-oxo-4H-1-benzopyran-3-carbonitrile 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Tricyclic aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2

Aminocyanopyridine compounds are described which are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2. Pharmaceutical compositions and kits are also described, which include an anminocyanopyridine MK-2 inhibiting compound.

Studies on antianaphylactic agents. 7. Synthesis of antiallergic 5-oxo-5H-[1]benzopyrano[2,3-b]pyridines

5-Oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acids 23 and their tetrazole analogues 24 were synthesized from 4-oxo-4H-1-benzopyran-3-carbonitriles or 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehydes. When administered intravenously, they exhibited antiallergic activity in a reaginic PCA test in rats. In the carboxylic acid series, the activity was influenced by the substituents at the 2-position and increased substantially in the following order: Me, OMe 2 OH, H NHOMe. On the other hand, in the tetrazole series, 2-unsubsitituted derivatives showed the highest activity. Regardless of the kinds of substituents at positions 2 and 3, compounds bearing an alkyl group, especially an isopropyl group at the 7-position, were superior in activity to the corresponding unsubstituted compounds. Among these alkyl derivatives, 3-carboxylic acid derivatives, i.e., 23c (7-ethyl), 23g (2-amino-7-isopropyl), 23r [2-(methoxyamino)-7-isopropyl], and a 3-tetrazole derivative 24c (7-isopropyl), were 41-184 times as potent as disodium cromoglycate. They also exhibited remarkable activity when administered orally; clinical studies on 23g (AA-673) are in progress.

SYNTHESIS OF 3-SUBSTITUTED-5-OXO-5H-BENZOPYRANOPYRIDINE DERIVATIVES

3-Cyano-. 3-alkoxycarbonyl-, and 3-formyl-5-oxo-5H-benzopyranopyridine dervatives were prepared by reactions of 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehydes 1 with acetylene derivatives (methods A-C) or with reactive methylene compounds (methods D-E) and also by catalytic hydrogenation of 2-chloro-5-oxo-5H-benzopyranopyridine-3-carbonitriles 12 (method F).