68306-14-9Relevant academic research and scientific papers
Cleavage and Reassembly of the C═O Bond of 2-Alkynylbenzaldehydes: A Metal-Free Access to Inden-1-ones
Ju, Ying,Liu, Tao,Tan, Jiajing,Yao, Tuanli,Zhang, Feng
, p. 9455 - 9465 (2021/07/26)
A metal-free approach to inden-1-ones from 2-alkynylbenzaldehydes mediated by pyrrolidine has been developed. The reaction proceeds under mild conditions in a step- and atom-economy process by cleaving the C═O bond and constructing new C-C as well as C═O bonds. Oxygen-18 and deuterium labeling experiments revealed an aza-Petasis-Ferrier rearrangement of an intermediate 1-amino-3-methylene-dihydroisobenzofuran.
Preparation method of indanone derivatives
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Paragraph 0070; 0071; 0072; 0073, (2018/03/02)
The invention relates to a synthesis method of organic compounds. In order to solve the problems of more reaction steps, more raw material variety and long reaction time in the current indanone derivative synthesis and relatively high catalyst price in some methods, the invention provides a preparation method of indanone and derivatives thereof. The indanone derivatives are prepared by reacting o-alkynylbenzaldehyde serving as an initial material with a catalyst, an oxidant and a solvent at 25-100 DEG C for 1-24h. The synthesis method is convenient to realize aftertreatment, simple and convenient to operate, incapable of producing waste acid in reaction, environment-friendly and capable of realizing a reaction under a relatively mild condition. The synthesis method is a novel route for synthesizing the indanone derivatives.
Stereoselective synthesis of hydroxy stilbenoids and styrenes by atom-efficient olefination with thiophthalides
Mitra, Prithiba,Shome, Brateen,Ranjan De, Saroj,Sarkar, Anindya,Mal, Dipakranjan
, p. 2742 - 2752 (2012/11/07)
The synthesis of stilbenoids and styryl carboxylic acids is accomplished with high E-stereoselectivity by olefination of aldehydes with thiophthalides under basic conditions. The olefination is highly atom-efficient as it only loses elemental sulfur during the reaction. This olefination, in conjunction with retro Kolbe-Schmitt reaction, allows facile synthesis of E-hydroxystilbenoids with minimal employment of protecting groups. This study also discloses two important findings: formation of i) 4-methylsulfanyl isocoumarins and ii) an 2-arylindenone. The Royal Society of Chemistry 2012.
