68306-22-9Relevant academic research and scientific papers
Catalytic Asymmetric Cycloadditions between Aldehydes and Enolizable Anhydrides: Cis-Selective Dihydroisocoumarin Formation
Aiello, Maria Luisa,Farid, Umar,Trujillo, Cristina,Twamley, Brendan,Connon, Stephen J.
, p. 15499 - 15511 (2018)
In the presence of a trityl-substituted cinchona alkaloid-based catalyst, homophthalic, aryl succinic, and glutaconic anhydride derivatives reacted with aromatic and aliphatic aldehydes to produce cis-lactones in up to 90:10 dr and 99% ee. A DFT study has shown how the catalyst is uniquely able to bring about the opposite sense of diastereocontrol to that usually observed.
