683202-57-5Relevant academic research and scientific papers
Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists
Griffith, David A.,Hargrove, Diane M.,Maurer, Tristan S.,Blum, Charles A.,De Lombaert, Stéphane,Inthavongsay, John K.,Klade, Lee E.,MacK, Christine M.,Rose, Colin R.,Sanders, Martin J.,Carpino, Philip A.
, p. 2641 - 2645 (2011/06/20)
A novel series of pyrazolo[1,5-a]pyrimidine derivatives was synthesized and evaluated as NPY Y1R antagonists. High binding affinity and selectivity were achieved with C3 trisubstituted aryl groups and C7 substituted 2-(tetrahydro-2H-pyran-4-ylamino)ethyla
