683205-71-2Relevant academic research and scientific papers
Synthesis and biological activity of piperazine-Based dual MMP-13 and TNF-α converting enzyme inhibitors
Letavic, Michael A.,Barberia, John T.,Carty, Thomas J.,Hardink, Joel R.,Liras, Jennifer,Lopresti-Morrow, Lori L.,Mitchell, Peter G.,Noe, Mark C.,Reeves, Lisa M.,Snow, Sheri L.,Stam, Ethan J.,Sweeney, Francis J.,Vaughn, Marcie L.,Yu, Chul H.
, p. 3243 - 3246 (2007/10/03)
A series of novel MMP-13 and TNF-α converting enzyme inhibitors based on piperazine 2-hydroxamic acid scaffolds are described. The TACE, MMP-1 and MMP-13 activity of these inhibitors as well as the effect of substitution of the piperazine nitrogen and the P-1′ benzyloxy tailpiece is discussed. Moderate in vivo activity is observed with several members of this group.
