68321-58-4

Upstream product

• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 95-64-7 4-amino-o-xylene 

Downstream Products

• 68321-61-9 2-(3,4-dimethyl-phenyl)-5,7-dimethyl-2H,5H-pyrimido[4,5-e][1,2,4]triazine-3,6,8-trione 
• 76789-45-2 2-(3,4-Dimethyl-phenyl)-4-methyl-2H-[1,2,4]triazine-3,5-dione 
• 80999-75-3 8-[(3,4-Dimethyl-phenylamino)-methyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 57715-64-7 2-(3,4-dimethyl-phenyl)-2H-[1,2,4]triazine-3,5-dione 
• 68321-64-2 2-(3,4-dimethyl-phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid 
• 80999-71-9 (Z)-3-[5-(3,4-Dimethyl-phenylazo)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylamino]-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and antiviral and antitumor activities of 2H-[1,2,3]triazolo[4,5-d]pyrimidines and 1H-, 2H-, and 3H-[1,2,3] triazolo [4,5-d]pyrimidin-5(4H)-one-7(6H)-thiones

This paper describes a facile synthesis of 2-aryl-2H-[1,2,3]triazolo-[4,5-d]pyrimidine-5,7(4H,6H)-diones (3a-o) and 7-amino-2-aryl-5-phenyl-2H-[1,2,3]triazolo[4,5-d]pyrimidines (6a-e) prepared by oxidative cyclization of 6-amino-5-arylazopyrimidine-2,4(1H-3H)-diones (2a-o) and 4,6-diamino-5-arylazo-2-phenylpyrimidines (5a-e) with CUSO4, respectively, and a reliable thionation of [1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-diones (3a,e,f, 7a,b and 9) accomplished by the reaction with phosphorous pentasulfide or Lawesson's reagent as well as evaluation of their antiviral and antitumor activities in vitro.