683210-70-0Relevant articles and documents
Azasugar-Based MMP/ADAM Inhibitors as Antipsoriatic Agents
Moriyama, Hideki,Tsukida, Takahiro,Inoue, Yoshimasa,Yokota, Kohichi,Yoshino, Kohichiro,Kondo, Hirosato,Miura, Nobuaki,Nishimura, Shin-Ichiro
, p. 1930 - 1938 (2007/10/03)
As a part of synthetic studies on MMP (matrix metalloproteinase)/ADAM (a disintegrin and metalloproteinase) inhibitors, we have preliminarily communicated that azasugar-based compound 1a exhibited a potential inhibitory activity on some metalloprotease-ca
Synthesis and biological activity of selective azasugar-based TACE inhibitors
Tsukida, Takahiro,Moriyama, Hideki,Inoue, Yoshimasa,Kondo, Hirosato,Yoshino, Kohichiro,Nishimura, Shin-Ichiro
, p. 1569 - 1572 (2007/10/03)
A series of azasugar-based hydroxamic acid derivatives bearing 2R,3R,4R,5R-configuration is described. Compound 4c with 4,5-O-acetonide group showed excellent in vitro potency against TACE, with high selectivity over MMP-1 and moderate selectivity over MM