683215-19-2

Usage

Structure

A derivative of malonic acid with a 3-chlorobenzyl group attached

Appearance

White to off-white crystalline solid

Solubility

Slightly soluble in water

Applications

Organic synthesis, pharmaceutical research, building block for organic compound synthesis, precursor for pharmaceutical drug production, potential biological activities for drug discovery and development.

Upstream product

• 70146-77-9 [(3-chlorophenyl)methyl]propanedioic acid dirthyl ester 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 
• 108-41-8 1-chloro-3-methylbenzene 

Downstream Products

• 21640-48-2 3-chlorohydrocinnamic acid 
• 1956-15-6 3-chlorophenylalanine 

Relevant academic research and scientific papers

Synthesis and insecticidal activity of mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety

Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism.

METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.