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683241-92-1

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  • 1-Piperazinecarboxylic acid, 4-(5-carboxy-3-chloro-2-pyridinyl)-, 1-(1,1-dimethylethyl) ester

    Cas No: 683241-92-1

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683241-92-1 Usage

General Description

6-[4-(tert-butoxycarbonyl)piperazin-1-yl]-5-chloronicotinic acid is a chemical compound that contains a piperazine ring and a chloronicotinic acid group. The tert-butoxycarbonyl (Boc) protecting group on the piperazine ring is commonly used in organic synthesis to protect the amine from unwanted reactions. The chloronicotinic acid group is a derivative of nicotinic acid, which is a precursor to the coenzyme nicotinamide adenine dinucleotide (NAD). 6-[4-(tert-butoxycarbonyl)piperazin-1-yl]-5-chloronicotinic acid may have potential applications in medicinal chemistry, as piperazine derivatives are known for their pharmacological activities, and nicotinic acid derivatives are used in the preparation of drugs. The specific properties and potential uses of this compound would require further investigation and research.

Check Digit Verification of cas no

The CAS Registry Mumber 683241-92-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,3,2,4 and 1 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 683241-92:
(8*6)+(7*8)+(6*3)+(5*2)+(4*4)+(3*1)+(2*9)+(1*2)=171
171 % 10 = 1
So 683241-92-1 is a valid CAS Registry Number.

683241-92-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-chloro-6-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]pyridine-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 4-(5-carboxy-3-chloro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:683241-92-1 SDS

683241-92-1Relevant articles and documents

Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor

Bach, Peter,Bostr?m, Jonas,Brickmann, Kay,Van Giezen,Groneberg, Robert D.,Harvey, Darren M.,O'Sullivan, Michael,Zetterberg, Fredrik

supporting information, p. 360 - 375 (2013/10/01)

The present paper describes the development of a new series of P2Y 12 receptor antagonists based on our previously reported piperazinyl urea series 1 (IC50 binding affinity = 0.33 μM, aq solubility 50 binding affinity = 0.042 μM, aq solubility = 90 μM, microsomal CLint (HLM) = 70 μM/min/mg). Further improvements in affinity and metabolic stability were achieved by replacing the central piperazine ring with a 3-aminoazetidine as exemplified by 3 (IC50 binding affinity = 0.0062 μM, aq solubility = 83 μM, microsomal CLint (HLM) = 28 μM/min/mg). The improved affinity observed in the in vitro binding assay also translated to the potency observed in the WPA aggregation assay (47: 19 nM and 3: 9.5 nM) and the observed in vitro ADME properties translates to the in vivo PK properties observed in rat. In addition, we found that the chemical stability of the sulfonylureas during prolonged storage in solution was related to the sulfonyl urea linker and depended on the type of solvent and the substitution pattern of the sulfonyl urea functionality.

Novel CXCR3 antagonists with a piperazinyl-piperidine core

McGuinness, Brian F.,Carroll, Carolyn DiIanni,Zawacki, Lisa Guise,Dong, Guizhen,Yang, Cangming,Hobbs, Doug W.,Jacob-Samuel, Biji,Hall III, James W.,Jenh, Chung-Her,Kozlowski, Joseph A.,Anilkumar, Gopinadhan N.,Rosenblum, Stuart B.

scheme or table, p. 5205 - 5208 (2010/03/31)

High-throughput screening of an encoded combinatorial aryl piperazine library led to the identification of a novel series of potent piperazinyl-piperidine based CXCR3 antagonists. Analogs of the initial hit were synthesized via solid and solution phase me

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H- benzimidazoles

Ognyanov, Vassil I.,Balan, Chenera,Bannon, Anthony W.,Bo, Yunxin,Dominguez, Celia,Fotsch, Christopher,Gore, Vijay K.,Klionsky, Lana,Ma, Vu V.,Qian, Yi-Xin,Tamir, Rami,Wang, Xianghong,Xi, Ning,Xu, Shimin,Zhu, Dawn,Gavva, Narender R.,Treanor, James J. S.,Norman, Mark H.

, p. 3719 - 3742 (2007/10/03)

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).

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