683246-81-3Relevant academic research and scientific papers
Copper sulfate-pentahydrate-1,10-phenanthroline catalyzed amidations of alkynyl bromides. Synthesis of heteroaromatic amine substituted ynamides
Zhang, Yanshi,Hsung, Richard P.,Tracey, Michael R.,Kurtz, Kimberly C. M.,Vera, Eymi L.
, p. 1151 - 1154 (2004)
(Equation presented) A practical cross-coupling of amides with alkynyl bromides using catalytic CuSO4·5H2O and 1,10-phenanthroline is described here. This catalytic protocol is more environmentally friendly than the use of CuCN or copper halides and provides a general entry for syntheses of ynamides including various new sulfonyl and heteroaromatic amine substituted ynamides. Given the interest in ynamides, this N-alkynylation of amides should be significant for the future of ynamides in organic synthesis.
