683246-82-4

Upstream product

• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 397333-58-3 ((3-bromoprop-2-yn-1-yl)oxy)(tert-butyl)diphenylsilane 
• 88159-06-2 tert-butyl(diphenyl)(2-propynyloxy)silane 
• 253681-50-4 tert-butyldiphenylsilyl 3,3-dibromoprop-2-en-1-yl ether 

Downstream Products

• 950777-54-5 (E)-N-benzyl-N-(3-hydroxyprop-1-en-1-yl)-4-methylbenzenesulfonamide 
• 950777-88-5 N-benzyl-N-{(E)-3-[(prop-2-ynyl)oxy]prop-1-enyl}-4-methylbenzenesulfonamide 
• 950777-91-0 N-benzyl-N-{(E)-3-[(3-trimethylsilylprop-2-ynyl)oxy]prop-1-enyl}-4-methylbenzenesulfonamide 
• 1029537-64-1 N-benzyl-N-{(E)-3-[2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]-oxazol-3-yl)-2-oxoethoxy]propen-1-yl}-4-methylbenzenesulfonamide 
• 1300117-22-9 N-benzyl-N-[(4R,5S)-4-((3S,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazole-3-carbonyl)-2,2-dimethyl-[1,3]dioxan-5-yl]-4-methylbenzenesulfonamide 
• 1029537-93-6 N-benzyl-N-[(1R)-1-(hydroxymethyl)propyl]-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Copper-mediated selective cross-coupling of 1,1-dibromo-1-alkenes and heteronucleophiles: Development of general routes to heterosubstituted alkynes and alkenes

Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing

Synthesis of 1,2-amino alcohols by sigmatropic rearrangements of 3-(N-Tosylamino)allylic alcohol derivatives

Sigmatropic rearrangements of 3-(N-tosylamino)allylic alcohol derivatives, a particular subclass of functionalized enamides, have been investigated. Whereas the presence of the nitrogen atom alters the stereochemical outcome of Ireland-Claisen rearrangeme

Stereoselective synthesis of 1,2-aminoalcohols by [2,3]-wittig rearrangements

[2,3]-Wittig rearrangements of (E)-3-aza-allylic alcohol derivatives can provide access to functionalized 1,2-aminoalcohols with high syn or anti diastereoselectivity depending on the anionic stabilizing group (amide or alkyne). American Chemical Society.

Copper sulfate-pentahydrate-1,10-phenanthroline catalyzed amidations of alkynyl bromides. Synthesis of heteroaromatic amine substituted ynamides

(Equation presented) A practical cross-coupling of amides with alkynyl bromides using catalytic CuSO4·5H2O and 1,10-phenanthroline is described here. This catalytic protocol is more environmentally friendly than the use of CuCN or copper halides and provides a general entry for syntheses of ynamides including various new sulfonyl and heteroaromatic amine substituted ynamides. Given the interest in ynamides, this N-alkynylation of amides should be significant for the future of ynamides in organic synthesis.