683275-32-3

Upstream product

• 265648-28-0 N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide 
• 22440-58-0 (E)-4-nitrocinnamic acid chloride 
• 882-06-4 4-nitro-trans-cinnamic acid 
• 35675-44-6 4-methylphenylacetyl chloride 
• 1775-95-7 2-amino-5-nitrobenzophenone 
• 265648-27-9 N-(2-benzoyl-4-nitrophenyl)-2-(4-methylphenyl)acetic acid amide 

Relevant academic research and scientific papers

Structure - Activity relationships of novel anti-malarial agents. Part 2: Cinnamic acid derivatives

We have described compound 1 as a lead structure for a novel class of anti-malarial agents. Replacement of the 3-phenylpropionyl moiety of the lead structure 1 by a 4-propoxycinnamic acid residue resulted in a significant improvement in anti-malarial activity. Compound 3q represents an important step in the development of lead structure 1 into an anti-malarial drug candidate.

Non-thiol farnesyltransferase inhibitors: Utilization of the far aryl binding site by 5-cinnamoylaminobenzophenones

We recently described two novel aryl binding sites of farnesyltransferase. In this study, the cinnamoyl residue was designed as an appropriate substituent for our benzophenone-based AAX-peptidomimetic compound capable of occupying the far aryl binding site.

Non-thiol farnesyltransferase inhibitors: N-(4-Acylamino-3-benzoylphenyl)-4-nitrocinnamic acid amides

We have developed a 4-nitrocinnamoyl substituted benzophenone as a novel non-thiol farnesyltransferase inhibitor. Replacement of the p-tolyl moiety of our initial lead structure by different para and ortho substituted phenyl residues as well as by 1-naphthyl resulted in derivatives with considerably enhanced activity displaying IC50 values between 42 and 52 nM. These compounds represent novel, readily accessible non-thiol farnesyltransferase inhibitors being more active than the corresponding thiol-containing analogues. Copyright