683275-52-7Relevant academic research and scientific papers
Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin
Matthews, Jay M.,Liotta, Fina,Hageman, William,Rivero, Ralph A.,Westover, Lori,Yang, Maria,Xu, Jun,Demarest, Keith
, p. 1155 - 1159 (2004)
The use of a multiplex mimetic assay led us to identify 1,4-dihydropyrimidines with potent and selective calcitonin receptor mimetic activity. Subsequent modification of the dihydropyrimidine scaffold led to a series of molecules that were efficacious in a neonatal mouse calvaria in vitro model. Dihydropyrimidine 5h, in particular, was identified as a calcitonin mimetic (EC50=6 μM), active in-vivo in the Weanling rat model when administered subcutaneously.
