6833-02-9

Upstream product

• 110-94-1 1,5-pentanedioic acid 
• 2873-74-7 gloutaric dichloride 
• 62-53-3 aniline 
• 103-72-0 phenyl isothiocyanate 
• 5414-99-3 4-(phenylcarbamoyl)butyric acid 
• 222851-56-1 N-phenylsulfinylamine 

Downstream Products

• 62-53-3 aniline 
• 112167-47-2 4-(2,6-Dioxo-piperidin-1-yl)-benzenesulfonyl chloride 
• 123730-90-5 1-Phenyl-6-[(E)-phenylimino]-piperidin-2-one 
• 5768-13-8 N-phenylglutarimide 

Relevant academic research and scientific papers

Synthesis of N,N′-diarylalkanediamides and their antimycobacterial and antialgal activity

A set of N,N′-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N′-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacteri-ally active substances were found only in the series of N,N′-diarylethanediamides and N,N′-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antial-gal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes.

A convenient acylation procedure of alcohols and amines

The reaction of carboxylic acids with primary and secondary alcohols in the presence of aromatic sulfochlorides (mesitylenesulfonyl chloride and 2,4,6-triisopropylbenzenesulfonyl chloride) or aromatic sulfotetrazoles (mesytilenesulfonyl tetrazolide and 2,4,6-triisopropylbenzenesulfonyltetrazole) and usual acylation catalysts was shown to be a convenient procedure for the synthesis of esters. Reaction of carboxylic acids with primary aliphatic or aromatic amines in the presence of the same tetrazolides and catalysts is a useful procedure for the synthesis of amides. Syntheses of twenty compounds are presented as examples.

SYNTHESIS AND REACTIONS OF N-(p-CHLOROSULPHONYLPHENYL)-SUCCINIMIDE, -GLUTARIMIDE AND -CAMPHORIMIDE

N-Phenyl-succinimide, -glutarimide and -camphorimide mreact with chlorosulphonic acid to yield the corresponding sulphonyl chlorides.Condensation with nucleophiles afforded 25 sulphonyl derivatives, which are to be examined for biocidal properties. reacti

Reaction of Phenyl Isothiocyanate with Some α,N-Acylamino and Dicarboxylic Acids

Dianilides are obtained in the reaction of phenyl isothiocyanate with dicarboxylic acids, such as oxalic, malonic, glutaric and adipic acids, and not in the case of succinic and phthalic acids.In the case of succinic acid, the product is monoanilide, dianilide or N-phenylsuccinimide, depending upon the reaction conditions.Phthalic acid always gives N-phenylphthalimide.N-Acylamino acids on reaction with phenyl isothiocyanate yield the corresponding anilides.The probable mechanisms of this reaction are discussed.