68337-15-5

Usage

Chemical Properties

beige-brownish powder

Uses

4-(1H-1,2,4-Triazol-1-yl)phenol can be used for its anti-inflammatory properties.

Upstream product

• 68377-33-3 1-(4-methoxyphenyl)-1H-[1,2,4]triazole 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 68377-33-3 1-(4-methoxyphenyl)-1H-[1,2,4]triazole 
• 1027991-64-5 {5-[3-(4-[1,2,4]triazol-1-yl-phenoxy)-propoxy]-indan-1-yl}-acetic acid ethyl ester 
• 123916-00-7 O-[4'(1H-1,2,4-Triazol-1-yl)phenyl]dimethylthiocarbamate 
• 446018-49-1 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid 4-[1,2,4]triazol-1-yl-phenyl ester 
• 733748-42-0 1-[5-nitro-6-(4-[1,2,4]triazol-1-yl-phenoxy)-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester 
• 1196485-51-4 4-[4-(4-[1,2,4]triazol-1-yl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 860298-75-5 2-nitro-5-[4-(1H-1,2,4-triazol-1-yl)phenoxy]pyridine 
• 263152-07-4 1-(4-methoxyphenyl)-1H-[1,2,4]triazol-4-ium-4-methoxybenzoyl-2,4,6-trinitrophenylmethylide 
• 263152-06-3 1-(4-methoxyphenyl)-1H-[1,2,4]triazol-4-iumbenzoyl-2,4,6-trinitrophenylmethylide 

Relevant academic research and scientific papers

4-(1H-1,2,4-Triazol-1-yl)phenol

The secondary structure of the title compound, C8H7N3O, consists of O-H...N hydrogen-bonding catemers, similar to those of the parent 1,2,4-triazole, where the molecules are linked by N-H...N bonds. Chains related by translation are linked by C-H(triazole)...O/N interactions to give a tertiary structure of corrugated sheets parallel to the ac plane. The quaternary structure is due to C-H(Ph)...O contacts and to the stacking of triazole rings from centrosymmetrically related sheets.

N-terminal strategy (N1-N4) toward high performance liquid crystal materials

Liquid crystal materials have a variety of applications in many fields such as display techniques as well as photonics and optics. However, only few design principles have been disclosed on liquid crystal materials with different N-heterocycles as the terminal groups, which hinder the development of the heterocyclic liquid crystals. Here, a strategy of molecular design for N-heterocyclic liquid crystal materials is reported. On the basis of this strategy, a series of convenient N-heterocycles such as pyrrole, pyrazole, imidazole, 1,2,3-triazole, 1,2,4-triazole, 1,2,3,4-tetrazole were applied to synthesize the novel liquid crystals. Most of them have proved to exhibit good mesomorphic behaviors which make them excellent components in the mixture of the LCDs materials. The simple attachment of N-heterocyclic units to the liquid crystal molecules through a mild reaction condition will provide a good prospect for the design of N-heterocyclic liquid crystals.

Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles

Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles, useful as antifungal and antibacterial agents.

Synthesis and analgesic-antiinflammatory activity of some 4- and 5-substituted heteroarylsalicylic acids

We have made a series of 4- and 5-aryl- and 4- and 5-heteroarylsalicylic acid derivatives with the objective of reducing gastric irritation and increasing potency. Here we describe a series of 4- and 5-heterocyclic salicylic acids and their antiinflammatory-analgesic potencies measured in comparison to aspirin. An improvement of the therapeutic index over aspirin of 100 was achieved; however, the heterocyclic salicylic acids lacked antipyretic activity. Some physicochemical parameters which may bear on the antiinflammatory activity of these compounds are discussed.