68341-09-3

Basic information

• Product Name: [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
• Synonyms: [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper;Cu-ASTM;CuII(atsm);Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II);CUAM;Cu-ATSM
• CAS NO: 68341-09-3
• Molecular Formula: C8H14CuN6S2
• Molecular Weight: 321.91296
• Mol File: 68341-09-3.mol
• Article Data: 0

Chemical Properties

• Appearance: , brown to dark red-brown/
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble10mg/mL, clear
• CAS DataBase Reference: [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper(CAS DataBase Reference)
• NIST Chemistry Reference: [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper(68341-09-3)
• EPA Substance Registry System: [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper(68341-09-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 68341-09-3(Hazardous Substances Data)

Usage

Uses

Cu-ATSM is preclinically used as a potential therapy for ALS (amyotrophic lateral sclerosis). A potential anti-Alzheimer''s agent.

Biochem/physiol Actions

Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. CuII(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.