6836-10-8Relevant articles and documents
-
Carmack et al.
, p. 4110 (1959)
-
Generating skeletal diversity from the C19-diterpenoid alkaloid deltaline: A ring-distortion approach
Chen, Qi-Feng,Wang, Feng-Peng,Liu, Xiao-Yu
, p. 8946 - 8950 (2015)
The development of new drugs calls for large collections of diverse molecules with considerable complexity. Ring distortion of natural products provides an efficient and facile approach to access new architectures with intriguing biological activities, by harnessing their inherent complexity. In this study, such a strategy has been explored on an abundant C19-diterpenoid alkaloid, deltaline, enabling the synthesis of 32 new derivatives bearing a broad spectrum of unique scaffolds. Extensive spectroscopic studies including X-ray crystallographic analyses strongly supported the structures of the obtained novel skeletons, which present comparable opportunities with the great contributions made by nature for discovery of new lead compounds.
REACTION OF C19-DITERPENE ALKALOIDS WITH SODIUM IN LIQUID AMMONIA
Narzullaev, A. S.,Yunusov, M. S.,Moiseenkov, A. M.,Sabirov, S. S.
, p. 321 - 323 (2007/10/02)
The reaction of C19 -diterpene alkaloids with sodium and liquid ammonia in the presence and in the absence of a proton donor - an alcohol - has been investigated.In the absence of the proton donor the hydroxy group is converted into a carbonyl group, which is characteristic only for C-6-hydroxy or -acetoxy derivatives.
