6836-48-2

Basic information

• Product Name: Naphthalene, 6-(bromomethyl)-1,2,3,4-tetrahydro-
• Synonyms: Naphthalene, 6-(bromomethyl)-1,2,3,4-tetrahydro- ;6-(BROMOMETHYL)-1,2,3,4-TETRAHYDRO-NAPHTHALENE
• CAS NO: 6836-48-2
• Molecular Formula: C₁₁H₁₃Br
• Molecular Weight: 225.12492
• Mol File: 6836-48-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Naphthalene, 6-(bromomethyl)-1,2,3,4-tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: Naphthalene, 6-(bromomethyl)-1,2,3,4-tetrahydro-(6836-48-2)
• EPA Substance Registry System: Naphthalene, 6-(bromomethyl)-1,2,3,4-tetrahydro-(6836-48-2)

Safety Data

• Hazardous Substances Data: 6836-48-2(Hazardous Substances Data)

Usage

General Description

Naphthalene, 6-(bromomethyl)-1,2,3,4-tetrahydro- is a chemical compound that is a derivative of naphthalene, which consists of two fused benzene rings. The bromomethyl group attached to the 6th position of the naphthalene ring makes it a useful building block in organic synthesis, particularly for the creation of various pharmaceuticals and agrochemicals. The tetrahydro moiety in the compound indicates that it has a saturated four-membered ring, which can affect its chemical and biological properties. Naphthalene, 6-(bromomethyl)-1,2,3,4-tetrahydro- may have potential applications in the development of new drug molecules or as a reagent in organic chemistry reactions.

Upstream product

• 1131-63-1 1,2,3,4-tetrahydro-2-naphthoic acid 
• 23194-33-4 methyl 5,6,7,8-tetrahydronaphthalene-2-carboxylate 
• 6883-81-4 6-hydroxymethyl-1,2,3,4-tetrahydronaphthalene 

Downstream Products

• 53618-53-4 (5,6,7,8-Tetrahydro-naphthalen-2-ylmethanesulfinyl)-acetic acid 4-nitro-benzyl ester 
• 53618-54-5 (5,6,7,8-Tetrahydro-naphthalen-2-ylmethanesulfinyl)-acetic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 166519-73-9 (2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(5,6,7,8-tetrahydro-naphthalen-2-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 158574-75-5 [(S)-1-(Benzyl-methyl-carbamoyl)-2-(5,6,7,8-tetrahydro-naphthalen-2-yl)-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN)

Antivirulence strategies are now attracting interest for the inherent mechanism of action advantages. In our previous work, diapophytoene desaturase (CrtN) was identified to be an attractive and drugable target for fighting pigmented S. aureus infections. In this research, we developed a series of effective benzocycloalkane-derived CrtN inhibitors with submicromolar IC50. Analogue 8 blocked the pigment biosynthesis of three MRSA strains with a nanomolar IC50 value. Corresponding to its mode of action, 8 did not function as a bactericidal agent. 8 could sensitize S. aureus to immune clearance. In vivo, 8 was proven to be efficacious in an S. aureus Newman sepsis model and abscess formation model. For two typical MRSAs, USA400 MW2 and Mu50, 8 significantly decreased the staphylococcal loads in the liver and kidneys. Moreover, 8 showed minimal antifungal activity compared to that of NTF. In summary, 8 has the potential to be developed as a therapeutic drug, especially against intractable MRSA issues.