68367-53-3

Usage

Uses

Used in Organic Synthesis:
1,2-BIS(DIMETHYLAMINO)-2-METHYLPROPANE is used as a catalyst for the formation of urethanes and epoxides, facilitating efficient and versatile organic synthesis reactions.
Used in Catalyst Complexation:
1,2-BIS(DIMETHYLAMINO)-2-METHYLPROPANE is used as a catalyst in complexation processes to form low-coordinate transition metal complexes, enhancing the reactivity and selectivity of certain chemical reactions.
Used in Strong Base Reactions:
1,2-BIS(DIMETHYLAMINO)-2-METHYLPROPANE is used as a strong base in reactions such as the deprotection of silyl ethers and the alkylation of sulfones, providing a robust alternative to traditional bases in these applications.
Used in Chemical Industry:
1,2-BIS(DIMETHYLAMINO)-2-METHYLPROPANE is used as a catalyst and strong base in the chemical industry for various synthesis and reaction processes, contributing to the production of a wide range of chemical products.

InChI:InChI=1/C8H20N2/c1-8(2,10(5)6)7-9(3)4/h7H2,1-6H3

Upstream product

• 50-00-0 formaldehyd 
• 811-93-8 1,1-dimethylethylenediamine 

Relevant academic research and scientific papers

Bulky Diamine Ligand Promotes Cross-Coupling of Difluoroalkyl Bromides by Iron Catalysis

Although iron-catalyzed cross-coupling of Grignard reagents with alkyl halides has been well established, the adoption of the reaction for fluoroalkylations has not been reported because traditional catalytic systems often lead to defluorination reactions. Described herein is the investigation of an iron-catalyzed cross-coupling between arylmagnesium bromides and difluoroalkyl bromides with modified N,N,N′,N′-tetramethyl-ethane-1,2-diamine (TMEDA) as a ligand. The use of this bulky diamine, in which a butylene is substituted at one carbon atom of the ethylene backbone in TMEDA, enables the iron-catalyzed difluoroalkylation under mild reaction conditions with a wide range of difluoroalkyl bromides, including vulnerable bromodifluoromethane, thus providing a general and cost-efficient route for applications in medicinal chemistry.

THE REACTIONS OF N,N-DIMETHYLPHOSPHORAMIDIC DIFLUORIDE WITH TRANS-2-SUBSTITUTED CYCLOALKANOLS

An interaction between N,N-dimethylphosphoramidic difluoride and cyclic alcohols containing hydroxyl, alkylamine and methylthiol groups in the trans-β-position was performed. Trans-1-ethylcyclopentane-1,2-diol and trans-2-(N-alkylamino)cyclopentanols react with N,N-dimethylphosphoramidic difluoride to yield 1-ethyl-6-oxabicyclo(3.1.0)hexane and 6-alkyl-6-azabicyclo(3.1.0)hexane, respectively. In the case of trans-2-(N,N-dialkylamino)cyclopentanols and cyclohexanols, such reaction gives a salt of phosphorodifluoridic acid and the corresponding cyclic N,N,N',N'-tetraalkyl-1,2-diamine whereas trans-2-methylthiocyclopentanol is converted to a salt of phosphorodifluoridic acid and N,N-dimethyl-N-(2-methylthiocyclopentyl)amine. Some of described reactions appear to be applicable for the synthesis of various organic compounds, e.g. phosphorylated 2-N,N-dialkylaminocyclopentanethiols. Key words: N,N-dimethylphosphoramidic difluoride, N,N-dimethylphosphoramidothioic difluoride, phosphorodifluoridic acid, phosphorylated dialkylaminocyclopentanethiol, N,N-dialkylaminocycloalkanol, N,N,N',N'-tetraalkyl-1,2-diamine.