68370-45-6Relevant articles and documents
Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives
Usuki, Toyonobu,Sato, Makiko,Hara, Shihori,Yoshimoto, Yukiko,Kondo, Ryosuke,Zimmermann, Stefanie,Kaiser, Marcel,Brun, Reto,Hamburger, Matthias,Adams, Michael
, p. 794 - 798 (2014)
Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. Recently, it was found that the compound is a potent in vitro and in vivo inhibitor of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis (HAT; sleeping sickness). In this Letter, chemical derivatization of cynaropicrin and the structure-activity-relationship (SAR) study against T. brucei is described.