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Ueber Pterinchemie. 73. Mitteilung. Zum Verlauf der katalytischen Reduktion von 7-Methylpterin
Ganguly, Abboy N.,Sengupta, Pradip K.,Bieri, Jost H.,Viscontini, Max
, p. 395 - 401 (2007/10/02)
The catalytic hydrogenation of 7-methylpterin (VII) in a neutral solution occurs first by the reduction of the 7,8-double bond (thermodynamically-controlled reaction) followed by the reduction of the 5,6-double bond.On the contrary, in an acidic medium like CF3COOH, the 5,6-double bond is reduced first (kinetically-controlled reaction).The dihydro-intermermediate then undergoes a -H-rearrangement leading to the formation of the thermodynamically more stable 7-methyl-7,8-dihydropterin (XV) which on further reduction gives 7-methyl-5,6,7,8-tetrahydropterin (VIII).The catalytic reduction of 7-methyl-7,8-dihydropterin (XV) with deuterium gives stereoselectively a sole product with D at C(6) in the equatorial position.
