68376-12-5Relevant academic research and scientific papers
Direct Assembly of Polysubstituted Naphthalenes via a Tandem Reaction of Benzynes and α-Cyano-β-methylenones
Wang, Qiang,An, Yi,Du, Guangfen,Cai, Zhi-Hua,Dai, Bin,He, Lin
, p. 14210 - 14218 (2020)
A mild and transition-metal-free benzannulation reaction for the construction of the naphthalene skeleton has been described. Benzynes react with α-cyano-β-alkylenones through a tandem nucleophilic addition/cyclization/aromatization process to afford polysubstituted naphthalenes in 50-94% yields.
