68376-31-8

Basic information

• Product Name: (phenyl)[2-(tosylmethyl)phenyl]methanone
• Synonyms: (phenyl)[2-(tosylmethyl)phenyl]methanone
• CAS NO: 68376-31-8
• Molecular Weight: 350.438
• Mol File: 68376-31-8.mol

Chemical Properties

• CAS DataBase Reference: (phenyl)[2-(tosylmethyl)phenyl]methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (phenyl)[2-(tosylmethyl)phenyl]methanone(68376-31-8)
• EPA Substance Registry System: (phenyl)[2-(tosylmethyl)phenyl]methanone(68376-31-8)

Safety Data

• Hazardous Substances Data: 68376-31-8(Hazardous Substances Data)

Upstream product

• 31378-03-7 1-phenyl-2-tosylethanone 
• 5023-60-9 1-benzylsulfanyl-4-methyl-benzene 
• 611-73-4 Benzoylformic acid 
• 131-58-8 2-Methylbenzophenone 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

A novel multicomponent reaction of arynes, β-keto sulfones, and Michael-type acceptors: A direct synthesis of polysubstituted naphthols and naphthalenes

(Chemical Equation Presented) A novel multicomponent reaction of arynes, β-keto sulfones, and Michael-type acceptors is presented, providing an efficient method for the synthesis of polysubstituted naphthols and polysubstituted naphthalenes. Further investigation suggests that the tandem reaction may proceed via a sequential nucleophilic attack to arynes, intramolecular nucleophilic substitution followed by a Michael addition, and a ring closure - elimination process.

Sulfonylation of Benzylic C?H Bonds through the Reaction of Aryl(o-tolyl)methanones with Sulfonyl Hydrazides or Sulfonyl Chlorides

A sulfonylation of benzylic C?H bonds of aryl(o-tolyl)methanones with arylsulfonyl hydrazides or arylsulfonyl chlorides has been developed. Arylsulfonyl hydrazides and arylsulfonyl chlorides were employed as sulfonylating reagents respectively to complete this transformation. During the reaction, enols were generated in situ from aryl(o-tolyl)methanones under UV irradiation, and subsequently reacted with sulfonyl radicals to provide a range of aryl(2-(arylsulfonylmethyl)aryl)methanones.

Palladium-catalyzed C-H acylation of arenes using thioethers as directing groups

A highly efficient protocol for regioselective synthesis of diaryl ketones by palladium-catalyzed direct acylation of arenes using thioethers as directing groups is reported. The possible pathway of direct acylation between thioethers and α-oxocarboxylic acids is discussed. The direct acylation of thioethers via Pd-catalyzed C-H bond activation was described. Copyright