68382-46-7Relevant academic research and scientific papers
The: Z -enoate assisted, Meyer-Schuster rearrangement cascade: Unconventional synthesis of α-arylenone esters
Tharra, Prabhakararao,Baire, Beeraiah
, p. 12147 - 12150 (2016)
Br?nsted acid promoted nucleophilation of propargylic alcohols during the Meyer-Schuster rearrangement (M-S) has been introduced. A novel concept of reverse polarization of the M-S intermediate allenyl cation has been realized by employing a cis-enoate as
THERAPEUTIC COMPOUNDS AND USES THEREOF
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Page/Page column 82; 83, (2016/08/23)
The present invention relates to compounds of formula (I): and to salts thereof, wherein R1-R6 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of TAF1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various TAF1-mediated disorders.
Facile preparation of allenic hydroxyketones via rearrangement of propargylic alcohols
Jung, Michael E.,Pontillo, Joseph
, p. 367 - 369 (2008/02/11)
(equation presented) Treatment of tertiary propargylic alcohols 13 with 3-diazo-2-butanone 6 and catalytic dirhodium tetraacetate in benzene gave good yields of the diastereomeric allenic hydroxyketones 14, with, in some cases, good diastereocontrol. Thes
PROSTANOIDS. XIII. SYNTHESIS OF THE 15- AND 16-METHYL DERIVATIVES OF THE ω-PHENOXY ANALOGS OF 11-DEOXYPROSTAGLANDINS E1
Tolstikov, G. A.,Miftakhov, M. S.,Danilova, N. A.,Shitikova, O. V.
, p. 74 - 80 (2007/10/02)
(+/-)-11-Deoxy-16-phenoxy-15-methyl-ω-tetranorprostaglandin E1 and 11,15-dideoxy-16-hydroxy-17-phenoxy-16-methyl-ω-trinor-α-homoprostaglandin E1 were synthesized by the 1,4-conjugate addition of the cuprate rea
PROSTANOIDS. V. THE ω-CHAIN FOR 16-ARYLOXYTETRANORPROSTAGLANDINS
Tolstikov, G. A.,Miftakhov, M. S.,Danilova, N. A.,Galin, F. Z.
, p. 1624 - 1631 (2007/10/02)
During hydrostannylation of 4-aryloxy-3-hydroxy-1-butynes and subsequent cleavage of the obtained E-vinylstannates with iodine the corresponding E-1-iodo-3-hydroxy-4-aryloxy-1-butenes were synthesized.
Prostaglandin derivatives having alkynyl, hydroxy and aryloxy junctions in the 2β side chain
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, (2008/06/13)
The present invention encompasses compounds of the formula: STR1 wherein n is 0 or 1; Y represents ethylene or vinylene; R represents hydrogen or lower alkyl having 1-7 carbon atoms; R', R", R'" each individually represent hydrogen or methyl; Ar represent
