6839-11-8

Usage

1-Naphthalenemethanol, a-(3-methoxyphenyl)(Norephedrine) properties and specific content

A combination of carbon (C), hydrogen (H), nitrogen (N), and oxygen (O) atoms that make up the compound's structure.

Chiral molecule

Two enantiomers, (1R,2S)-norephedrine and (1S,2R)-norephedrine
A molecule with a central carbon atom (called a stereocenter) that has four different groups attached, resulting in two mirror-image forms that are not superimposable.

Stimulant

Increases alertness, energy, and focus
Norephedrine stimulates the central nervous system, leading to heightened mental and physical activity.

Sympathomimetic agent

Mimics the effects of the body's own adrenaline (epinephrine)
Norephedrine activates the sympathetic nervous system, which is responsible for the "fight or flight" response, causing increased heart rate, blood pressure, and metabolism.

Releasing agent for norepinephrine

Promotes the release of norepinephrine in the brain
Norephedrine enhances the release of norepinephrine, a neurotransmitter involved in regulating attention, alertness, and mood.

Nasal decongestant

Relieves nasal congestion by constricting blood vessels in the nasal passages
Norephedrine reduces swelling and inflammation in the nasal passages, making it easier to breathe.

Appetite suppressant

Reduces hunger and promotes weight loss
Norephedrine can increase metabolism and suppress appetite, making it a potential aid for weight management.

Recreational drug misuse

Stimulant properties can lead to abuse and addiction
The stimulating effects of norephedrine can be addictive, leading to misuse and potential health risks.

Schedule II controlled substance

Regulated in the United States and other countries
Due to its potential for abuse and addiction, norephedrine is classified as a Schedule II controlled substance, which means it has a high potential for abuse and can lead to severe psychological or physical dependence.

Upstream product

• 90-11-9 1-Bromonaphthalene 
• 591-31-1 3-methoxy-benzaldehyde 
• 90-14-2 1-Iodonaphthalene 

Downstream Products

• 109251-88-9 3-Methoxyphenyl 1-naphthyl ketone 
• 193217-31-1 (+/-) 4-((α-Hydroxy)-1-naphtylmethyl)-N,N-diethylbenzamide 
• 193217-17-3 3-methoxyphenyl(2-naphthyl)methanol 
• 193217-16-2 3-methoxy-α-(1-naphthyl)benzyl chloride 

Relevant academic research and scientific papers

CoI-Catalyzed Barbier Reactions of Aromatic Halides with Aromatic Aldehydes and Imines

The reductive Barbier coupling of aromatic halides and electrophiles has been achieved using a CoBr2/1,10-phenanthroline catalytic system and over stoichiometric amounts of zinc. The reaction displayed a broad scope of substrates, including (hetero)aryl chlorides as pro-nucleophiles and aldehydes or imines as electrophiles, leading to diarylmethanols and diarylmethylamines in moderate to excellent yields, respectively.

Compounds with analgesic effect

PCT No. PCT/SE96/01635 Sec. 371 Date Apr. 24, 1997 Sec. 102(e) Date Apr. 24, 1997 PCT Filed Dec. 11, 1996 PCT Pub. No. WO97/23466 PCT Pub. Date Jul. 3, 1997Compounds of the formula (I) as well as their pharmaceutically acceptable salts, and pharmaceutical compositions comprising the novel compounds. The novel compounds of the formula (I) are useful in the management of pain.

Benzylation via Tandem Grignard Reaction - Iodotrimethylsilane (TMSI) Mediated Reduction

A method has been developed which allows for the large scale preparation of biarylmethanes.This method involves the initial formation of biarylmethanols via reaction of aryl Grignards with carbonyl compounds followed by a subsequent reduction with iodotrimethylsilane (TMSI).A number of improvements over existing literature procedures are reported as well as previously unobserved dimerizations.Studies reveal that as few as 3 equiv of TMSI will give complete reduction in most cases where either of the substituents are not heteroaromatic.Mono-substituted alkanols react with TMSI to afford the corresponding iodides.A mechanistic study of the TMSI reduction is also reported.