68395-80-2

Basic information

• Product Name: 2-TERT-BUTYL-5-PHENYLOXAZOLE
• Synonyms: 2-TERT-BUTYL-5-PHENYLOXAZOLE
• CAS NO: 68395-80-2
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.26
• Mol File: 68395-80-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-TERT-BUTYL-5-PHENYLOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TERT-BUTYL-5-PHENYLOXAZOLE(68395-80-2)
• EPA Substance Registry System: 2-TERT-BUTYL-5-PHENYLOXAZOLE(68395-80-2)

Safety Data

• Hazardous Substances Data: 68395-80-2(Hazardous Substances Data)

Upstream product

• 630-18-2 tert-butyl isocyanide 
• 3282-32-4 2-diazo-acetophenone 
• 3969-09-3 2-methyl-5-phenyl-1,3-oxazole 
• 74-88-4 methyl iodide 
• 754-10-9 2,2-dimethylpropionamide 
• 6607-46-1 (1,2-dibromovinyl)benzene 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 19881-88-0 N-(2,2-Dimethylpropanoyl)phenylalanin 
• 62056-54-6 N-(β-Phenetyl)-2,2-dimethylpropionsaeureamid 

Relevant articles and documents

Iodine catalysed intramolecular C(sp3)-H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

Iodine catalyzed synthesis of 2,5-disubstituted oxazoles from N-arylethylamides through intramolecular C(sp3)-H functionalization under metal-free conditions is described. The method is tolerable to a wide range of substrates having a variety of functional groups with moderate to good yields of the products.

Room temperature copper(II)-catalyzed oxidative cyclization of enamides to 2,5-disubstituted oxazoles via vinylic C-H functionalization

A copper(II)-catalyzed oxidative cyclization of enamides to oxazoles via vinylic C-H bond functionalization at room temperature is described. Various 2,5-disubstituted oxazoles bearing aryl, vinyl, alkyl, and heteroaryl substituents could be synthesized in moderate to high yields. This reaction protocol is complementary to our previously reported iodine-mediated cyclization of enamides to afford 2,4,5-trisubstituted oxazoles.

A domino copper-catalyzed C-N and C-O cross-coupling for the conversion of primary amides into oxazoles

A variety of oxazoles can efficiently be prepared, in a single step and in good yield, from primary amides and 1,2-dihaloalkenes using copper-catalysis. This new method allows the regioselective formation of a range of substituted oxazoles. The required 1,2-dihaloalkenes can prepared by simple treatment of alkynes with elemental bromine or iodine. Georg Thieme Verlag Stuttgart.