68401-66-1

Usage

Uses

Used in Organic Synthesis:
O-(2,2,2-Trifluoroethyl)hydroxylamine hydrochloride is used as a reagent in organic synthesis for its ability to generate nitrogen-based compounds, which is crucial in the production of pharmaceuticals and agrochemicals.
Used in Chemical Production:
In the Chemical Production Industry, O-(2,2,2-Trifluoroethyl)hydroxylamine hydrochloride is used as a precursor for the synthesis of various chemicals and materials, including polymers and dyes, due to its capacity to form stable and functional nitrogen-containing compounds.
Used in Medical Research:
O-(2,2,2-Trifluoroethyl)hydroxylamine hydrochloride is used as a research tool in medical research for its potential applications in studying neurodegenerative diseases and as a possible treatment for certain conditions, leveraging its unique chemical properties to explore new therapeutic avenues.
Safety Considerations:
It is important to handle O-(2,2,2-Trifluoroethyl)hydroxylamine hydrochloride with care, as it is considered hazardous. Its use should be restricted to trained professionals operating within a controlled laboratory environment to ensure safety and proper utilization of its properties.

InChI:InChI=1/C2H4F3NO.ClH/c3-2(4,5)1-7-6;/h1,6H2;1H

Downstream Products

• 1372793-65-1 cis-benzyl 3-((2,2,2-trifluoroethoxy)imino)butanoate 

Relevant academic research and scientific papers

ARYLAMIDINE DERIVATIVE, SALT THEREOF AND ANTIFUNGAL CONTAINING THESE

An arylamidine derivative represented by the general formula (wherein R 1 represents optionally protected or substituted amidino; and R 2 and R 3 are the same or different and each represents hydrogen or halogeno) or a salt of the derivative. The derivati

Studies on anti-MRSA parenteral cephalosporins II. Synthesis and antibacterial activity of 7 β-[2-(5-Amino-1,2,4-thiadiazol-3-yl)- 2(Z)-alkoxyiminoacetamido]-3(substituted imidazo[1,2-b] pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and related compounds

In an effort to discover a novel cefozopran (CZOP) derivative having excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), we performed chemical modification of the alkoxyimino moiety and imidazo[1,2-b]pyridazinium group of CZOP. Among the prepared compounds, the cyclopentyloxyimino derivative 7β-[2-(5- amino-1,2, 4-thiadiazol-3-yl)-2(Z) -cyclopentyloxyiminoacetamido] -3-(3,6-diaminoimidazo[1,2- b]pyridazinium-1-yl)methyl-3-cephem-4-carboxylate (20g) showed the most potent anti-MRSA activity, reflecting its high affinity (IC50=1.6μg/ml) for penicillin binding protein 2' (PBP2'), although its anti-MRSA activity was slightly inferior to that of vancomycin (VCM). In experimental systemic infection in mice, however, 20g showed activity comparable to that of VCM against MRSA. In addition, 20g showed activity similar or slightly inferior to that of CZOP against Pseudomonas aeruginosa both in vitro and in vivo. Considering its favorable antibacterial activity profile, 20g was considered to be the most promising CZOP derivative for further studies.