68402-57-3Relevant articles and documents
Regioselectivity control in Diels-Alder reactions of surfactant 1,3- dienes with surfactant dienophiles
Jaeger, David A.,Su, Dan,Zafar, Abdullah,Piknova, Barbora,Hall, Stephen B.
, p. 2749 - 2757 (2007/10/03)
The ability of surfactant aggregate-H2O interfaces to control the regioselectivity of Diels-Alder reactions has been investigated. Cycloadditions of surfactant 1,3-dienes 2-[[3-(dimethyldodecylsilyl)-1,3- butadien-2-yl]thio]-N,N,N-trimethyl-1-ethanaminium iodide (1a) and 6-[[3- (dimethyloctylsilyl)-1,3-butadien-2-yl]thio]-N,N,N-trimethyl-1-hexanaminium iodide (1b) with surfactant dienophiles (E)-2-[[[2- (dodecoxycarbonyl)ethenyl]carbonyl]oxy]-N,N,N-trimethyl-1-ethanaminium iodide (2a) and (E)-6-[[[2-(octoxycarbonyl)ethenyl]carbonyl]oxy]-N,N,N-trimethyl-1- hexanaminium bromide (2b) within their aqueous mixed micelles have been performed at 25(35) °C. The cycloaddition of 1a and 2a gave a 30:1 ratio of trans-1-[(2-trimethylammonio)ethylthio]-2-(dimethyldodecylsilyl)-4- (dodecoxycarbonyl)-5-[(2-trimethylammonio)ethoxycarbonyl]-1-cyclohexene dihalide (15a) and trans-1-[(2-trimethylammonio)ethylthio]-2- (dimethyldodecylsilyl)-4-[(2-trimethylammonio)ethoxycarbonyl]-5- (dodecoxycarbonyl)-1-cyclohexene dihalide (16a), respectively, and that of 1b and 2b a 6.6:1 ratio of trans-1-[(6-trimethylammonio)hexylthio]-2- (dimethyloctylsilyl)-4-(octoxycarbonyl)-5-[6- (trimethylammonio)hexoxycarbonyl]-1-cyclohexene dihalide (15b) and trans-1- [(6-trimethylammonio)hexylthio]-2-(dimethyloctylsilyl)-4-[6- (trimethylammonio)hexoxycarbonyl]-5-(octoxycarbonyl)-1-cyclohexene dihalide (16b), respectively. The excess of 15 over 16 is consistent with the reaction of 1 and 2 within mixed aggregates in their preferred orientations at the aggregate-H2O interface. The greater regioselectivity obtained in the reaction of 1a and 2a is ascribed to the shorter tether between their reactive functional groups and quaternary ammonium headgroups. A monolayer study of 15a and 16a was also performed.
Pharmaceutical diketopiperazine compounds
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, (2008/06/13)
A diketopiperazine of formula (I): STR1 wherein each of R7 and R8 which may be the same or different; is hydrogen or a nitro group; Y is STR2 --O-- or --S--, wherein each of R9 and R10 which may be the same or different, is hydrogen or a nitro group; n is 0, 1 or 2; m is an integer of 1 to 6; each R6, which may be the same or different, is a C1 -C6 alkyl group; and X is selected from (i) a phenyl group of the following formula STR3 and the salts and esters thereof; have activity as inhibitors of plasminogen activator inhibitor.