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1-Piperazinecarboxylic acid, 4-Imidazo[1,2-a]pyridin-5-yl-, 1,1-Dimethylethyl ester, also known as 4-Ipezil, is a chemical compound with potential pharmaceutical applications. It is a derivative of piperazine and imidazopyridine and has been studied for its potential use in the treatment of neurodegenerative disorders such as Alzheimer's disease. 1-Piperazinecarboxylic acid, 4-iMidazo[1,2-a]pyridin-5-yl-, 1,1-diMethylethyl ester has been shown to have acetylcholinesterase inhibitory activity, which is a key target for Alzheimer's disease therapy. Additionally, it has been reported to have potential antipsychotic and anxiolytic properties, making it a promising candidate for further research and development in the field of central nervous system therapeutics.
Used in Pharmaceutical Industry:
1-Piperazinecarboxylic acid, 4-Imidazo[1,2-a]pyridin-5-yl-, 1,1-Dimethylethyl ester is used as a potential therapeutic agent for the treatment of neurodegenerative disorders such as Alzheimer's disease. Its acetylcholinesterase inhibitory activity makes it a promising candidate for Alzheimer's disease therapy.
1-Piperazinecarboxylic acid, 4-Imidazo[1,2-a]pyridin-5-yl-, 1,1-Dimethylethyl ester is also used as a potential antipsychotic and anxiolytic agent due to its reported properties, making it a candidate for further research and development in the field of central nervous system therapeutics.

684222-75-1

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684222-75-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 684222-75-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,4,2,2 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 684222-75:
(8*6)+(7*8)+(6*4)+(5*2)+(4*2)+(3*2)+(2*7)+(1*5)=171
171 % 10 = 1
So 684222-75-1 is a valid CAS Registry Number.

684222-75-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-imidazo[1,2-a]pyridin-5-ylpiperazine-1-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:684222-75-1 SDS

684222-75-1Downstream Products

684222-75-1Relevant academic research and scientific papers

Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active Factor Xa inhibitors

Imaeda, Yasuhiro,Kawamoto, Tetsuji,Tobisu, Mamoru,Konishi, Noriko,Hiroe, Katsuhiko,Kawamura, Masaki,Tanaka, Toshimasa,Kubo, Keiji

, p. 3125 - 3140 (2008)

We have recently reported the discovery of orally active sulfonylalkylamide Factor Xa (FXa) inhibitors, as typified by compound 1 (FXa IC50 = 0.061 μM). Since the pyridylpiperidine moiety was not investigated in our previous study, we conducted detailed structure-activity relationship studies on this S4 binding element. This investigation led to the discovery of piperazinylimidazo[1,2-a]pyridine 2b as a novel and potent FXa inhibitor (FXa IC50 = 0.021 μM). Further modification resulted in the discovery of 2-hydroxymethylimidazo[1,2-a]pyridine 2e (FXa IC50 = 0.0090 μM), which was found to be a selective and orally bioavailable FXa inhibitor with reduced CYP3A4 inhibition.

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