684287-01-2

Upstream product

• 86386-65-4 1-[(4-fluorophenyl)methyl]-2,5-pyrrolidinedione 
• 321970-25-6 1-benzyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester 

Downstream Products

• 684287-02-3 carbonic acid 3-benzyl-6-(4-fluorobenzyl)-8-hydroxy-5,7-dioxo-3,5,6,7-tetrahydro-1,3,6-triaza-s-indacen-4-yl ester ethyl ester 
• 684287-03-4 carbonic acid 8-benzhydryloxy-3-benzyl-6-(4-fluorobenzyl)-8-hydroxy-5,7-dioxo-3,5,6,7-tetrahydro-1,3,6-triaza-s-indacen-4-yl ester ethyl ester 
• 684287-04-5 4-benzhydryloxy-1-benzyl-6-(4-fluorobenzyl)-8-hydroxy-1H-1,3,6-triaza-s-indacene-5,7-dione 
• 684287-06-7 4-benzhydryloxy-1-benzyl-6-(4-fluorobenzyl)-7-hydroxy-8-methoxy-6,7-dihydro-1H-1,3,6-triaza-s-indacen-5-one 
• 684287-05-6 4-benzhydryloxy-1-benzyl-6-(4-fluorobenzyl)-8-methoxy-1H-1,3,6-triaza-s-indacene-5,7-dione 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring

This communication details both the syntheses and biological evaluation of a novel class of HIV-1 integrase inhibitors. When the quinoline moiety is replaced with the quinoxoline moiety, the antiviral activity is significantly compromised. Similarly, intr

PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS

Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.