68454-19-3Relevant academic research and scientific papers
Synthesis of benzofurans from the cyclodehydration of α-phenoxy ketones mediated by Eaton’s reagent
Ma, Lin,Ma, Zhanwei,Zhang, Min,Zhou, Min
, p. 426 - 436 (2020/03/23)
Cyclodehydration of α-phenoxy ketones promoted by Eaton’s reagent (phosphorus pentoxide–methanesulfonic acid) is used to prepare 3-substituted or 2,3-disubstituted benzofurans with moderate to excellent yields under mild conditions. The method provides a facile access to benzofurans from readily available starting materials such as phenols and α-bromo ketones. The reaction is highly efficient, which is attributed to the good reactivity and fluidity of Eaton’s reagent. The reaction can be applied to prepare naphthofurans, furanocoumarins, benzothiophenes, and benzopyrans.
α-methylene-γ-butyrolactones: new inhibitors of platelet aggregation
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, (2008/06/13)
The present inventors have discovered three classes of novel α-methylene-γ-butyrolactones with excellent antiplatelet activity. As a result of intensive studies, it has been found that compounds represented by the formula I-III are potent inhibitors of platelet aggregation. STR1 For the formula I, R1 is a methyl, a phenyl group optionally substituted with one or two group selected from halide, (C1 -C4) alkyl, (C1 -C4) alkoxy, phenyl, nitro, amino. For the formula II, R1 is a methyl, a phenyl group optionally substituted with one or two group selected from halide, (C1 -C4) alkyl, (C1 -C4) alkoxy, phenyl, nitro, amino; R2 represents hydrogen, halide, (C1 -C4) alkyl, phenyl, nitro, amino; R3 represents hydrogen, halide, (C1 -C4) alkyl, phenyl, nitro, amino. For the formula III, R1 is a methyl, a phenyl group optionally substituted with one or two group selected from halide, (C1 -C4) alkyl, (C1 -C4) alkoxy, phenyl, nitro, amino; R4 represents hydrogen, hydroxy, (C1 -C4) alkyl. The present invention also provides a cost-efficient method for the preparation of formula I-III. Formula I-III may be administered orally or parenterly with an inert diluent or with a pharmaceutically acceptable carrier in the treatment or the prevention of cardiovascular disease.
Synthesis and evaluation of coumarin α-methylene-γ-butyrolactones: A new class of platelet aggregation inhibitors
Chen, Yeh-Long,Wang, Tai-Chi,Liang, Shiu-Chuan,Teng, Che-Ming,Tzeng, Cherng-Chyi
, p. 1591 - 1595 (2007/10/03)
In a search for new inhibitors of platelet aggregation, certain coumarin-hearing α-methylene-γ-butyrolactones were synthesized and evaluated for inhibitory activity against thrombin (Thr)-, arachidonic acid (AA)-, collagen (Col)-, and platelet-activating
