6846-03-3 Usage
Uses
Used in Pharmaceutical Industry:
Bradykinin Acetate is used as a pharmaceutical agent for its various physiological effects. It is employed in the development of drugs targeting blood pressure regulation, fluid and electrolyte balance, and smooth muscle contraction.
Used in Research Applications:
Bradykinin Acetate is used as a research tool in the study of its effects on vasodilation, capillary permeability, and other physiological processes. It helps researchers understand the underlying mechanisms of these processes and develop potential therapeutic agents.
Used in Drug Delivery Systems:
Bradykinin Acetate can be incorporated into drug delivery systems to enhance its therapeutic effects and bioavailability. Various carriers, such as organic and metallic nanoparticles, can be employed to improve the delivery and efficacy of Bradykinin Acetate in treating specific conditions.
Biological Activity
bradykinin (acetate) is a well-known 9-amino acid endogenous vasoactive peptide and a systemic vasodilator [1].bradykinin is a potent endothelium-dependent vasodilator, leading to the reduction in blood pressure. it also induces contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain. bradykinin is an inflammatory mediator. the bradykinin b1 receptor is expressed only as a result of tissue injury and plays a role in inflammation. the bradykinin b2 receptor is constitutively expressed and participates in bradykinin's vasodilatory role.in cultured endothelial cells, bradykinin promoted a rapid dissociation of the enos:b2 receptor complex [2]. in the mouse gastrointestinal tract and pancreas, bradykinin stimulated extravasation from postcapillary venules by two- to sevenfold by interacting with b2 receptors and stimulating tachykinin release from sensory nerves [3].in healthy men, bradykinin (100-3200 ng/kg min) dose-related increased plasma concentrations of 6-oxo-pgf1a , the stable hydrolysis product of prostacyclin (pgi2). so bradykinin may have a use as a probe of pg12 production in vivo in pathological states [1].
Biochem/physiol Actions
Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.
references
[1]. barrow se, dollery ct, heavey dj, et al. effect of vasoactive peptides on prostacyclin synthesis in man. br j pharmacol. 1986 jan;87(1):243-7.[2]. ju h, venema vj, marrero mb, et al. inhibitory interactions of the bradykinin b2 receptor with endothelial nitric-oxide synthase. j biol chem. 1998 sep 11;273(37):24025-9.[3]. figini m, emanueli c, grady ef, et al. substance p and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. am j physiol. 1997 apr;272(4 pt 1):g785-93.
Check Digit Verification of cas no
The CAS Registry Mumber 6846-03-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,4 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6846-03:
(6*6)+(5*8)+(4*4)+(3*6)+(2*0)+(1*3)=113
113 % 10 = 3
So 6846-03-3 is a valid CAS Registry Number.
