68469-19-2Relevant academic research and scientific papers
Synthesis of Heterocycles. Part VII . Synthesis and Antimicrobial Activity of Some 7H-s-Triazolothiadiazine and s-Triazolothiadiazole Derivatives
Eweiss, N. F.,Bahajaj, A. A.
, p. 1173 - 1182 (2007/10/02)
The cyclization of 4-amino-5-aryl-3-cyanomethylthio-1,2,4-triazoles II in the presence of concentrated sulfuric acid yields 7H-6-amino-s-triazolothiadiazines III.Cyclization of 4-amino-5-aryl-1,2,4-triazole-3-thiones I with phenacyl chloride yields 7H-3-aryl-6-phenyl-s-triazolothiadiazines IV.Similarly, compounds I condensed with cyanogen bromide, phenyl isothiocyanate and carbon disulfide to give the corresponding cyclized products 6-amino-3-aryl-s-triazolothiadiazoles V, 3-aryl-6-phenylamino-s-triazolothiadiazoles VI and 3-aryl-s-triazolothiadiazol-6(5H)thiones VII, respectively.Also in the presence of phosphoryl chloride, compounds I underwent cyclization with monocarboxylic acids and oxalic acid to 3,6-diaryl-s-triazolothiadiazole VIII and 6,6'-bis(3-aryl-s-triazolothiadiazoles) IX.The above compounds were screened for their antimicrobial activity.
Bridgehead Nitrogen Heterocycles : Novel Reactions of 5-Aryl-4-amino-3-mercapto-4H-1,2,4-triazoles
Dash, B.,Dora, E. K.,Panda, C. S.
, p. 369 - 371 (2007/10/02)
The reactions of 5-aryl-4-amino-3-mercapto-4H-1,2,4-triazoles (I, R=C6H5, o-ClC6H4, C6H5CH2-) with phenacyl bromide, dimedone, benzoin, chloroacetyl chloride, carbon disulphide and tetracyclone furnish the condensed products whose structures have been ass
