68469-26-1Relevant academic research and scientific papers
Synthesis and reactions of some new 1,2,4-triazine derivatives of biological interest
El-Brollosy, Nasser R.
, p. 77 - 89 (2007/10/03)
4-Amino-3-mercapto-6-methyl-1,2,4-triazin-5(4H)-one (1) and its 5-thioxo derivative 4 were reacted with phenacyl halides at different reaction conditions to yield the S-phenacyl derivatives 2a,b, 5 as well as the corresponding triazino[3,4-b][1,3,4]thiadiazines 3a,b, 6. Treatment of 1 with acrylonitrile gave 4-amino-3-(2-cyanoethyl)thio-6-methyl-1,2,4-triazin-5(4H)-one (7), which was condensed with various aldehydes to afford the corresponding anils 10a-c. Acid hydrolysis of 10b gave the corresponding acid 11, whereas 7 yielded 4-amino-3-hydroxy-6-methyl-5(4H)-oxo-1,2,4-triazine hydrochloride (12) under the same condition. Some new compounds exhibited antibacterial and antifungal activities.
