68485-39-2Relevant academic research and scientific papers
Olivanic Acid Analogues. Part 2. Total Synthesis of Some C(6)-Substituted 7-Oxo-1-azabicyclohept-2-ene-2-carboxylates
Bateson, John H.,Quinn, Alison M.,Smale, Terence C.,Southgate, Robert
, p. 2219 - 2234 (2007/10/02)
A number of 6-substituted 7-oxo-1-azabicyclohept-2-ene-2-carboxylates related to the olivanic acids were prepared from the phosphorane (32).Generation of the anion α to the azetidin-2-one carbonyl group, followed by reaction with electrophiles and intramolecular cyclisation using the Wittig procedure gave the bicyclic products; in all cases the thermodynamically favoured trans-stereochemisty about the azetidinone ring predominated.In contrast, some less readily available cis-substituted analogues were obtained from the cyclohexa-1,4-diene derived phosphorane (61).The synthetic utility of a masked acetonyl ester group for preparing the free acids of these azabicycloheptene ring systems is described.
4-Allyl azetidinone intermediate for β-lactam antibacterial agents
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, (2008/06/13)
Compounds are provided of the formula (II): STR1 wherein R1 is a group such that CO2 R1 is an ester group and A1 is a hydrogen atom or a methyl group. These compounds possess antibacterial activity. The preparat
β-Lactam antibacterial agents
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, (2008/06/13)
Compounds are described of the formula (II): STR1 wherein R1 is a group such that CO2 R1 is an ester group; A1 is a hydrogen atom; and A2 is a group CR2 R3 R4 wherein
Bicyclic β-lactam antibiotics
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, (2008/06/13)
Compounds of the formula (I): STR1 wherein G is hydrogen, alkyl, alkenyl, substituted alkyl or substituted alkenyl, R1 is alkyl or aryl, substituted alkyl or substituted aryl, and R is an organic group such that --CO2 R is an ester group are produced. The compounds are useful as antibacterial and β-lactamase inhibitory agents.
