68505-86-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-1-(4-hydroxy-3-methoxyphenyl)propan-1-one is used as a chemical reagent for the synthesis of 2-amino-4-arylthiazole. This synthesized compound serves as an inhibitor of 3D polymerase, which is crucial in the treatment of foot-and-mouth disease (FMD). By targeting the 3D polymerase enzyme, 2-amino-4-arylthiazole can effectively combat the replication of the virus responsible for FMD, offering a potential therapeutic solution for this infectious disease.

Upstream product

• 1835-14-9 1-(4'-hydroxy-3'-methoxyphenyl)propan-1-one 

Relevant academic research and scientific papers

Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD)

Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of livestock caused by a highly variable RNA virus, foot-and-mouth disease virus (FMDV). One of the targets to suppress expansion of and to control FMD is 3D polymerase (FMDV 3Dpol). In this study, 2-amino-4-arylthiazole derivatives were synthesized and evaluated for their inhibitory activity against FMDV 3Dpol. Among them, compound 20i exhibited the most potent functional inhibition (IC50 = 0.39μM) of FMDV 3D polymerase and compound 24a (EC50=13.09 μM) showed more potent antiviral activity than ribavirin (EC50=1367 μM) and T1105 (EC50=347 μM) with IBRS-2 cells infected by the FMDV O/SKR/2010 strain.

Process for preparing a ketone

A process for preparing methyl vanillyl ketone from guaiacol is disclosed.