685111-94-8

Upstream product

• 329325-42-0 (+)-(R)-1-(pyridin-4-yl)-1,3-propanediol 
• 591228-11-4 3-hydroxy-3-(pyridin-4-yl)propionic acid ethyl ester 
• 1027138-30-2 ethyl 3-(L-2-N,N-dimethylamino-3-phenyl-propanoyloxy)-3-(pyridin-4-yl)-propanoate 
• 872-85-5 pyridine-4-carbaldehyde 
• 777-52-6 1-dichlorophosphoryloxy-4-nitro-benzene 

Relevant academic research and scientific papers

Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-β-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma

Cytotoxic nucleosides have proven to be ineffective for the treatment of hepatocellular carcinoma (HCC) due, in part, to their inadequate conversion to their active nucleoside triphosphates (NTP) in the liver tumor and high conversion in other tissues. Th

Novel cytarabine monophosphate prodrugs

Compounds of Formula I, their preparation and uses are described: wherein: M and V are cis to one another and MH is cytarabine; the 5′ oxygen of said cytarabine is attached to the phosphorus; V is 4-pyridyl; and pharmaceutically acceptable prodrugs and salts thereof.