685115-77-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(3,5-dichloropyridin-4-yl)piperidine-4-carboxamide is used as a potential pharmaceutical agent due to its unique chemical structure, which may offer therapeutic benefits in various medical applications. Its specific role and efficacy would need to be determined through additional research and clinical trials.
Used in Research Applications:
In the field of scientific research, 1-(3,5-dichloropyridin-4-yl)piperidine-4-carboxamide serves as a valuable compound for studying the effects of piperidine derivatives with substituted pyridine rings. It can be utilized in experiments to explore its chemical properties, interactions with biological systems, and potential applications in drug development.

Upstream product

• 39546-32-2 4-carboxamidopiperidine 
• 33216-52-3 3,4,5-trichloropyridine 

Downstream Products

• 1221567-23-2 1-(3-chloro-5-(3,4-dimethoxyphenyl)pyridin-4-yl)piperidine-4-carboxamide 
• 1221567-69-6 1-(3-chloro-5-(4-fluorophenyl)pyridin-4-yl)piperidine-4-carboxamide 
• 1221567-89-0 1-(3-chloro-5-(4-(dimethylamino)phenyl)pyridin-4-yl)piperidine-4-carboxamide 
• 1221567-62-9 1-(3-chloro-5-(4-methoxyphenyl)pyridin-4-yl)piperidine-4-carboxamide 
• 1221567-61-8 1-(3-chloro-5-phenylpyridin-4-yl)piperidine-4-carboxamide 

Relevant academic research and scientific papers

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen

WNT signaling is frequently deregulated in malignancy, particularly in colon cancer, and plays a key role in the generation and maintenance of cancer stem cells. We report the discovery and optimization of a 3,4,5-trisubstituted pyridine 9 using a high-throughput cell-based reporter assay of WNT pathway activity. We demonstrate a twisted conformation about the pyridine-piperidine bond of 9 by small-molecule X-ray crystallography. Medicinal chemistry optimization to maintain this twisted conformation, cognisant of physicochemical properties likely to maintain good cell permeability, led to 74 (CCT251545), a potent small-molecule inhibitor of WNT signaling with good oral pharmacokinetics. We demonstrate inhibition of WNT pathway activity in a solid human tumor xenograft model with evidence for tumor growth inhibition following oral dosing. This work provides a successful example of hypothesis-driven medicinal chemistry optimization from a singleton hit against a cell-based pathway assay without knowledge of the biochemical target.

PYRIDINE AND PYRIMIDINE BASED COMPOUNDS AS WNT SIGNALING PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER

The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and / or prevention of cancer.