685128-77-2 Usage
General Description
(5R)-2,2,3-TriMethyl-5-benzyl-4-iMidazolidinone is a chemical compound that belongs to the class of imidazolidinones. It is an organic compound that contains a five-membered ring structure with a benzyl group and three methyl groups attached to it. (5R)-2,2,3-TriMethyl-5-benzyl-4-iMidazolidinone is known for its use in various pharmaceutical and chemical industries, where it is used as a chiral auxiliary in asymmetric synthesis and as a building block for the synthesis of various biologically active compounds. Additionally, (5R)-2,2,3-TriMethyl-5-benzyl-4-iMidazolidinone has also been found to exhibit some pharmacological properties, making it a potential candidate for drug development and other medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 685128-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,5,1,2 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 685128-77:
(8*6)+(7*8)+(6*5)+(5*1)+(4*2)+(3*8)+(2*7)+(1*7)=192
192 % 10 = 2
So 685128-77-2 is a valid CAS Registry Number.
685128-77-2Relevant articles and documents
Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols
Nacsa, Eric D.,MacMillan, David W. C.
supporting information, p. 3322 - 3330 (2018/03/13)
Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated "spin-center shift" (SCS) mechanism. Alcohols, however, remain underused as alkylating agents in synthetic chemistry due to their low reactivity in two-electron pathways. We report herein an enantioselective α-benzylation of aldehydes using alcohols as alkylating agents based on the mechanistic principle of spin-center shift. This strategy harnesses the dual activation modes of photoredox and organocatalysis, engaging the alcohol by SCS and capturing the resulting benzylic radical with a catalytically generated enamine. Mechanistic studies provide evidence for SCS as a key elementary step, identify the origins of competing reactions, and enable improvements in chemoselectivity by rational photocatalyst design.
