685140-00-5Relevant academic research and scientific papers
P-Chirogenic Diaminophosphine Oxide: A New Class of Chiral Phosphorus Ligands for Asymmetric Catalysis
Nemoto, Tetsuhiro,Matsumoto, Takayoshi,Masuda, Takamasa,Hitomi, Tsukasa,Hatano, Keiichiro,Hamada, Yasumasa
, p. 3690 - 3691 (2007/10/03)
We successfully synthesized a novel P-chirogenic diaminophosphine oxide 4, which was applied to catalytic enantioselective construction of quaternary carbon centers using Pd-catalyzed asymmetric allylic substitution with various β-keto esters (up to 99% yield, 94% ee). Preliminary mechanistic studies indicated that two molecules of 8 coordinate to the Pd metal in a monodentate fashion, resulting in the formation of Pd complex 9 (Pd:8 = 1:2), which functions as the active species. Copyright
