685142-01-2

Upstream product

• 32771-73-6 2(R,S)-(2-amino-benzoylamino)-3-phenyl-propionic acid ethyl ester 
• 131172-64-0 4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid 
• 118-48-9 isatoic anhydride 
• 3182-93-2 ethyl 2-amino-3-phenylpropanoate hydrochloride 
• 65880-18-4 4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Anthranilic acid based CCK1 antagonists: The 2-indole moiety may represent a "needle" according to the recent homonymous concept

Recently we described an innovative class of non-peptide CCK1 antagonists keeping appropriate pharmacophoric groups on the anthranilic acid employed as a molecular scaffold. The lead compound obtained, VL-0395, characterized by the presence of Phe and the 2-indole moiety at the C- and N-termini of anthranilic acid, respectively, is endowed with submicromolar affinity towards CCK1 receptors. Thus, we have prepared and tested on CCK receptors a library of VL-0395 analogues in order to investigate the precise topological and essential key interactions of the 2-indole group of the lead with the CCK1 receptor. The obtained results confirm that this group establishes very specific interactions with this receptor sub-site and may be viewed as a "needle" group.