68535-57-9

Upstream product

• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 34259-99-9 4-bromo-1,3-thiazole 
• 3034-53-5 2-bromo-1,3-thiazole 
• 937-29-1 4-methoxybenzoyl bromide 
• 77287-34-4 formamide 

Downstream Products

• 53242-56-1 2-hydroxy-5-thiazol-4-yl-benzoic acid 
• 4795-88-4 1-isopropylamino-3-(4-thiazol-4-yl-phenoxy)-propan-2-ol 

Relevant academic research and scientific papers

Phosphonic acid derivatives and application thereof

The invention belongs to the field of medical chemistry, relates to phosphonic acid derivatives for treating virus infectious diseases and an application thereof, and in particular, relates to the compounds represented by the formula (I) or isomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, a preparation method thereof, pharmaceutical compositions containing the compounds and an application of the compounds or the compositions in preparation of drugs for treating the virus infection diseases.

NOVEL NUCLEOSIDE PHOSPHORAMIDATE COMPOUND AND USE THEREOF

The present invention provides a novel nucleoside phosphoramidate compound, or a stereoisomer, salt, hydrate, solvate or crystal thereof for the treatment of Flaviviridae family viral infection, especially hepatitis C viral infection. The present invention also provides the pharmaceutical composition comprising a compound of the present invention, or a stereoisomer, salt, hydrate, solvate or crystal thereof and a use of the compound or the composition of the present invention in the treatment of Flaviviridae family viral infection, especially hepatitis C viral infection. The compound of the present invention has a good anti-HCV effect.

Method for enhancement of chemiluminescence

A method for enhancing chemiluminescence which uses a heterocyclic compound of the formula: STR1 wherein R1 is an oxygen or sulfur atom or an imino group optionally substituted by 4-hydroxyphenyl, and R2, R3 and R4 are a hydrogen or halogen atom, an optionally substituted hydrocarbon residue, a heterocyclic group or the like in a luminescence system.

Synthesis and analgesic-antiinflammatory activity of some 4- and 5-substituted heteroarylsalicylic acids

We have made a series of 4- and 5-aryl- and 4- and 5-heteroarylsalicylic acid derivatives with the objective of reducing gastric irritation and increasing potency. Here we describe a series of 4- and 5-heterocyclic salicylic acids and their antiinflammatory-analgesic potencies measured in comparison to aspirin. An improvement of the therapeutic index over aspirin of 100 was achieved; however, the heterocyclic salicylic acids lacked antipyretic activity. Some physicochemical parameters which may bear on the antiinflammatory activity of these compounds are discussed.