68538-32-9Relevant academic research and scientific papers
5-fluorouracil derivatives. XXII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils
Ozaki, Shoichiro,Kong, Xiangzheng,Watanabe, Yutaka,Hoshiko, Tomonori,Koga, Toshikazu,Ogasawara, Tomio,Takizawa, Tsuneharu,Fujisawa, Hiroshi,Iigo, Masaaki,Hoshi, Akio
, p. 1372 - 1375 (2007/10/03)
Fifty-four 1-carbamoyl-5-fluorouracils were synthesized from 5- fluorouracil and isocyanate or amine. Antitumor activity was tested in the L- 1210 tumor system and 11 compounds gave better values of therapeutic ratio than HCFU (1-hexylcarbamoyl-5-fluorouracil). 1-(4- Methoxycyclohexylcarbamoyl)-5-fluorouracil gave the best result.
